15 February 2023: CoMiTED Non-Substantial Amendment 06 – approval
28 January 2023: The 25th participant was recruited to the CoMiTED trial
23 January 2023: CoMiTED Substantial Amendment 01 – approval
18 January 2023: CoMiTED Non-Substantial Amendment 05 – approval
15 December 2022: CoMiTED Non-Substantial Amendment 03 – approval
05 December 2022: 9 sites open to recruitment
17 October 2022: CoMiTED Non-Substantial Amendment 04 – approval
16 August 2022: North Bristol Trust recruited the first patient to the CoMiTED trial
08 August 2022: CoMiTED’s lead site, North Bristol Trust, opened to recruitment
01 August 2022: CoMiTED Non-Substantial Amendment 02 – approval
19 July 2022: CoMiTED Non-Substantial Amendment 01 – approval
23 May 2022: Research Ethics Committee (REC; Wales REC 4, reference 22/WA/0118) and Health Research Authority (HRA) and Health and Care Research Wales (HCRW) approval granted
